Thermo Fisher Scientific CD44 Monoclonal Antibody (OTI5B4), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:4,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD44 is a 100 kDa type I transmembrane glycoprotein expressed on human leukocytes, white matter of the brain, and certain epithelial cells. It serves as a receptor for hyaluronic acid (HA) and plays roles in cell-cell interactions, adhesion, and migration.
Multiple isoforms exist, with CD44H being predominant in normal tissues. CD44 expression may increase in certain carcinomas, potentially linked to metastatic potential.
CD44 is expressed in hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia of cultured keratinocytes. It is highly expressed in bone marrow myeloid cells and memory T cells, and can be upregulated in peripheral B and T cells upon stimulation.
Alternative splicing generates diverse isoforms, contributing to structural and functional variability.
Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be involved in tumor metastasis formation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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