Thermo Fisher Scientific c-Myc Monoclonal Antibody (9E10), DyLight 488
DyLight 488 형광 표지된 c-Myc 단일클론 항체(9E10)로, 인간 단백질 및 c-Myc 태그 단백질 검출에 적합합니다. Western blot과 면역세포염색(ICC/IF)에 사용 가능하며, 높은 특이성과 재현성을 제공합니다. 단백질 A 정제, 액상 형태, 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9E10 |
| Immunogen | Synthetic peptide A(408)-E E Q K L I S E E D L L R K R R E Q L K H K L E Q L R N S C A(438) of human c-Myc |
| Conjugate | DyLight™ 488 |
| Excitation/Emission Max | 492 / 519 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610623 |
Available Formats
Product Specific Information
- MA1-980-D488 detects c-Myc protein and c-Myc tagged proteins.
- Successfully used in fluorescent Western blot.
- DyLight 488 has excitation/emission maxima at 493/518 nm.
Target Information
The c-Myc protein (62 kDa) is a transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle regulation.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is functionally linked to proliferation control.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development.
Antibodies recognizing c-Myc epitopes detect overexpressed Myc-tagged proteins at either the N- or C-terminus.
Amplification or translocation of the c-Myc gene is associated with multiple cancers including lung, breast, colon, and Burkitt’s lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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