Thermo Fisher Scientific POMGNT1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

The POMGNT1 gene encodes protein O-mannose beta-1,2-N-acetylglucosaminyltransferase, which participates in O-mannosyl glycan synthesis. POMGnT1 is an N(in)/C(out) type II membrane protein localized in the medial-Golgi and initiates the conversion of high mannose N-glycans to complex N-glycans. It functions as a glycosylation enzyme involved in the synthesis of O-mannosyl glycan, a laminin-binding ligand of alpha-dystroglycan that is rarely synthesized in mammals. Mutations in the POMGNT1 gene cause muscle-eye-brain disease (MEB), an autosomal recessive disorder characterized by congenital muscular dystrophy, ocular abnormalities, and lissencephaly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.