Thermo Fisher Scientific Zap-70 Monoclonal Antibody (C.459.2)
Zap-70 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 Immunoprecipitation에 적합. 인체 시료에 반응하며 비특이적 교차반응 없음. 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C.459.2 |
| Immunogen | Synthetic peptide corresponding to residues surrounding the Ser289 of human Zap-70 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10979403 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other related proteins.
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase that belongs to the Syk family of proteins. It is expressed exclusively in T-cells and natural killer cells and is essential for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315, and 319 in the interdomain B region between the SH2 and kinase domains. Phosphorylation at tyrosines 315 (Vav binding site) and 319 (Lck binding site) enhances ZAP70-mediated lymphocyte signaling, while phosphorylation at tyrosine 292 attenuates activation and signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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