Thermo Fisher Scientific MT-ND2 Polyclonal Antibody
MT-ND2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC, ELISA에 적합하며 Human, Mouse, Rat 시료에 반응. Affinity chromatography로 정제된 액상 제품으로, -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 248–347 of human MT-ND2 (YP_003024027.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.72 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914172 |
Product Specific Information
- Positive test controls: Mouse brain, Rat brain
- Immunogen sequence:
LLSLGGLPPL TGFLPKWAII EEFTKNNSLI IPTIMATITL LNLYFYLRLI YSTSITLLPM SNNVKMKWQF EHTKPTPFLP TLIALTTLLL PISPFMLMIL
Target Information
MT-ND2:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain, where the immediate electron acceptor is ubiquinone.
Defects in MT-ND2 are associated with Leber hereditary optic neuropathy (LHON), a maternally inherited disease leading to acute or subacute loss of central vision due to optic nerve dysfunction. Cardiac conduction and neurological defects have been reported in some patients. LHON results from mitochondrial DNA mutations affecting respiratory chain complexes. MT-ND2 defects may also be linked to susceptibility to Alzheimer disease mitochondrial (AD-MT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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