Thermo Fisher Scientific CD71 (Transferrin Receptor) Recombinant Rabbit Monoclonal Antibody (JF0956)
CD71(Transferrin Receptor)에 특이적인 재조합 토끼 단클론 항체로, Western blot과 Flow Cytometry에 적합합니다. 높은 특이성과 민감도를 제공하며, 로트 간 일관성을 유지합니다. 동물 유래 성분이 없는 포뮬레이션으로 연구용에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | - |
| Flow Cytometry (Flow) | 1:50–1:100 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JF0956 |
| Immunogen | Synthetic peptide within Human CD71 (aa 22–60), target family: Transferrin Receptor (CD71), UniProt ID: P02786-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809777 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed in HEK293 cells. Individual clones are screened to select the best candidates for production.
Advantages:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to rabbit immune repertoire
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release, followed by recycling of the apotransferrin-receptor complex to the cell surface.
Transferrin receptor is essential for erythrocyte and nervous system development.
Serum transferrin receptor (sTfR) is used to detect erythropoietin (EPO) misuse and as a diagnostic marker for various anemias, including those associated with rheumatoid arthritis, pregnancy, irritable bowel syndrome, and HIV infection.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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