Thermo Fisher Scientific CD206 (MMR) Recombinant Rabbit Monoclonal Antibody (JF0953)
CD206(MMR) 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry 등에 사용 가능. 높은 특이성과 재현성을 제공하며, HEK293 발현 시스템 기반으로 생산. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 10 µg/mL |
| Immunohistochemistry (Frozen) (IHC-F) | – |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JF0953 |
| Immunogen | Synthetic peptide within Human CD206 aa 1,407–1,456 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.2% BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809775 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the pattern recognition receptor family. It is mainly expressed in tissue macrophages, dendritic cells, certain endothelial cells, and sperm cells.
CD206 plays a role in innate and adaptive immunity and mediates recognition and uptake of macromolecules such as modified lipoproteins, AGEs, and amyloid β-protein.
It is associated with cell adhesion, host defense, and diseases such as atherosclerosis, Alzheimer’s disease, leprosy, and Gaucher’s disease.
The CD206 gene encodes class A macrophage scavenger receptors (types 1, 2, 3), with type 3 acting as a dominant negative regulator of types 1 and 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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