Thermo Fisher Scientific Insulin/Proinsulin Monoclonal Antibody (D3E7 (5B6/6))

Applications and Tested Dilution

View 2 publications

Product Specifications

Product Specific Information

This product has an affinity of 6.3 × 10^8 M^-1.
Mouse anti-human Insulin/Proinsulin antibody, clone D3E7 (5B6/6), recognizes both insulin and proinsulin but does not react with free C-peptide.

Target Information

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein, and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids.

Insulin is a 51-amino acid polypeptide produced from a precursor peptide, proinsulin, which is post-translationally cleaved into two chains (peptide A and peptide B) covalently linked via two disulfide bonds and one molecule of C-peptide.

Insulin deficiency results in diabetes mellitus, a leading cause of morbidity and mortality. Insulin is also present in tumors of β-cell origin such as insulinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.