Thermo Fisher Scientific Insulin/Proinsulin Monoclonal Antibody (D6C4 (5E4/3))
인슐린 및 프로인슐린을 모두 인식하는 단클론 항체로, 인간·마우스·돼지 등 다양한 종에 반응합니다. ELISA 및 IHC(F) 등 연구용으로 적합하며, 높은 친화도(8.1×10^8 M^-1)를 가집니다. 장기 보관은 -20°C에서 권장됩니다.
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Pig, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | D6C4 (5E4/3) |
| Immunogen | Recombinant human insulin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | <0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_934316 |
Product Specific Information
This product has an affinity of 8.1×10^8 M^-1.
Mouse anti-human insulin/proinsulin antibody, clone D6C4 (5E4/3), recognizes both the pro and mature forms of human insulin but does not react with free C-peptide.
Target Information
Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein, and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids.
Insulin is a 51-amino acid polypeptide produced from the precursor peptide proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide.
Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality. Insulin is also present in tumors of β-cell origin, such as insulinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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