Thermo Fisher Scientific Insulin/Proinsulin Monoclonal Antibody (D6C4 (5E4/3))

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: Assay-dependent

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This product has an affinity of 8.1×10^8 M^-1.
Mouse anti-human insulin/proinsulin antibody, clone D6C4 (5E4/3), recognizes both the pro and mature forms of human insulin but does not react with free C-peptide.

Target Information

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein, and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids.
Insulin is a 51-amino acid polypeptide produced from the precursor peptide proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide.
Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality. Insulin is also present in tumors of β-cell origin, such as insulinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.