Thermo Fisher Scientific ZEB1 Monoclonal Antibody (OTI3G6), TrueMAB
ZEB1 단백질을 인식하는 Mouse Monoclonal Antibody로 Western Blot 및 IHC(Paraffin)에서 사용 가능. Human ZEB1에 특이적이며 ZEB2와 교차 반응 없음. 동결건조 형태로 제공되며, PBS buffer(8% trehalose) 내에 보존.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–350 of human ZEB1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
This ZEB1 antibody (TA802298) does not cross-react with ZEB2.
Target Information
ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. It modulates ATP1A1 promoter activity depending on cDNA quantity and cell type, represses E-cadherin promoters, and induces epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1.
ZEB1 also represses BCL6 transcription in the presence of CTBP1, positively regulates neuronal differentiation, and represses RCOR1 activation during neurogenesis.
Mutations in this gene can cause corneal dystrophy (posterior polymorphous) and Fuchs endothelial corneal dystrophy type 6.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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