Thermo Fisher Scientific ZEB1 Monoclonal Antibody (OTI9A3), TrueMAB
인간 ZEB1 단백질에 특이적인 단클론 항체로 WB 및 IHC(P) 분석에 적합. TrueMAB 형식으로 고순도 친화 크로마토그래피 정제. 동결건조 형태로 안정적 보관 가능하며, 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9A3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–350 of human ZEB1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor and inhibits IL-2 gene expression. It modulates promoter activity of the ATP1A1 gene depending on cDNA quantity and cell type.
ZEB1 represses E-cadherin promoters, inducing epithelial-mesenchymal transition (EMT) via SMARCA4/BRG1 recruitment. It also represses BCL6 transcription with CTBP1 corepressor, positively regulates neuronal differentiation, and represses RCOR1 activation during neurogenesis.
Mutations in ZEB1 may cause corneal dystrophy (posterior polymorphous and Fuchs endothelial type).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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