Thermo Fisher Scientific ZEB1 Monoclonal Antibody (OTI5B8), TrueMAB

Applications

• Western Blot (WB): 1:2,000 dilution tested

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. It modulates promoter activity of the ATP1A1 gene depending on cDNA quantity and cell type. ZEB1 represses E-cadherin promoters and induces epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. It also represses BCL6 transcription in the presence of CTBP1 and regulates neuronal differentiation by repressing RCOR1 activation during neurogenesis. Mutations in ZEB1 can cause corneal dystrophies such as posterior polymorphous and Fuchs endothelial dystrophy type 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.