Thermo Fisher Scientific Phospho-RelB (Ser552) Polyclonal Antibody
RelB 단백질의 Ser552 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin)에서 검증됨. Human, Mouse, Rat에 반응. 항원 친화 크로마토그래피로 정제, PBS 버퍼에 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human RelB around the phosphorylation site of Serine 552 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553768 |
Product Specific Information
- Detects endogenous RelB protein at approximately 70 kDa.
- Purity: >95% by SDS-PAGE.
Target Information
The NFκB transcription factor was originally identified as a protein complex consisting of a DNA-binding subunit and an associated protein. The DNA-binding subunit is functionally related to c-Rel p75 and RelB p68. The p50 subunit was initially believed to be a unique protein derived from the amino-terminus of a precursor designated p105. Another protein, p52 (previously referred to as p49), can act as an alternative NFκB subunit. RelB does not bind strongly to NFκB sites alone, but heterodimers between RelB and p50 bind with an affinity comparable to that of p50 NFκB homodimers. RelB/p50 heterodimers, unlike NFκB heterodimers, transactivate transcription of promoters containing κB binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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