Thermo Fisher Scientific Granzyme B Monoclonal Antibody (GZMB, 3014)
Granzyme B 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(P) 등 다양한 응용에 적합합니다. 단백질 A/G로 정제된 비표지 항체이며, 4°C에서 보관합니다. 세포독성 T세포 및 NK세포 연구용으로 적합합니다.
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- 3002-MSM4-P0
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GZMB, 3014 |
| Immunogen | Recombinant fragment of human GZMB protein (around aa 73–187) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
Granzyme B is a member of the granzyme serine protease family, found in the granules of cytotoxic T cells and NK cells. It is also known as CGL1 (cathepsin G-like-1) and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1). Granzyme B is crucial for inducing apoptosis in target cells through caspase activation and mitochondrial pathways. It cleaves caspase-3 and Bid protein, initiating DNA fragmentation. Granzymes are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and NK cells. Several granzymes (A–G) have been identified in mice, while fewer have been characterized in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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