Thermo Fisher Scientific Granzyme B Monoclonal Antibody (GZMB, 3055)
인간 Granzyme B를 인식하는 단클론 항체로, IHC(P) 및 Peptide Array에 사용 가능. Recombinant GZMB 단백질(aa 73-187)을 면역원으로 제작. 단클론 Mouse IgG(kappa) 형식이며, PBS(pH 7.4) 용액 형태로 제공. 연구용으로만 사용.
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- 3002-MSM5-P1ABX
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GZMB, 3055 |
| Immunogen | Recombinant fragment of human GZMB protein (around aa 73–187) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature (RT).
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at RT for 20 min.
Target Information
Granzyme B is a member of the granzyme serine protease family, found in cytotoxic T cells and NK cells. It is crucial for the induction of apoptosis in target cells through caspase-3 activation and mitochondrial pathways. Granzyme B interacts with the mannose 6-phosphate receptor, functioning as a death receptor during cytotoxic T cell-induced apoptosis. It can cleave Bid protein to trigger mitochondrial apoptosis. Granzymes (A–G) are neutral serine proteases stored in lytic granules of CTLs and NK cells. In humans, fewer granzymes have been cloned compared to mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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