Thermo Fisher Scientific Granzyme B Monoclonal Antibody (GZMB, 3014)
Human Granzyme B 단백질을 인식하는 Mouse 모노클로날 항체로, Western blot, IHC(P), Peptide Array에 사용 가능. Recombinant fragment(aa 73-187)을 면역원으로 제작. 단백질 A/G 정제, PBS buffer, 무보존제. 연구용으로만 사용.
- 카탈로그번호
- 3002-MSM4-P1ABX
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Granzyme B Monoclonal Antibody (GZMB, 3014)
Thermo Fisher Scientific Granzyme B Monoclonal Antibody (GZMB, 3014)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GZMB, 3014 |
| Immunogen | Recombinant fragment of human GZMB protein (around aa 73–187) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
Granzyme B is a member of the granzyme serine protease family found in the granules of cytotoxic T cells and NK cells. It is also known as CGL1 (cathepsin G-like-1) and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1). Granzyme B plays a crucial role in inducing apoptosis in target cells through caspase-3 activation and mitochondrial pathways involving Bid protein cleavage. It interacts with mannose 6-phosphate receptor functioning as a death receptor during cytotoxic T cell-induced apoptosis. Granzymes are neutral serine proteases stored in lytic granules of CTLs and NK cells. Several granzymes (A–G) have been identified in mouse cells, while fewer have been cloned in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.