Thermo Fisher Scientific Phospho-CDK6 (Tyr24) Polyclonal Antibody
CDK6 Tyr24 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 사람, 마우스, 랫트 반응성. 1 mg/mL 농도의 액상형, PBS/glycerol buffer에 보관. 세포주기 조절 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDK6 (Accession Q00534), corresponding to amino acid residues around phosphorylated Tyr24 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816158 |
Product Specific Information
This antibody detects endogenous levels of CDK6 only when phosphorylated at Tyr24.
Target Information
CDK6 functions as a cell-cycle initiator protein and is coexpressed and copurified with Cyclin D1. These proteins are critical regulators of cell cycle progression. CDK6, along with CDK4, is involved in the G1 to S phase transition. It is essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Mutations in the CDK6 gene are associated with microcephaly 12, primary, autosomal recessive (MCPH12).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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