Thermo Fisher Scientific Phospho-CDK6 (Tyr292) Polyclonal Antibody
CDK6의 Tyr292 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin) 분석에 적합. Human 및 Mouse 반응성. 고순도 정제, PBS/glycerol buffer 보존. 연구용 전용 제품.
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- PA5104684
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- pk
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Thermo Fisher Scientific Phospho-CDK6 (Tyr292) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDK6 (Accession Q00534), corresponding to amino acid residues around phosphorylated Tyr292 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816159 |
Product Specific Information
Antibody detects endogenous levels of CDK6 only when phosphorylated at Tyr292.
Target Information
CDK6 functions as a cell-cycle initiator protein and is coexpressed and copurified with Cyclin D1. These proteins are critical regulators of cell cycle progression. The prototype member of this family, p34cdc2, and the related protein CDK2, function late in the cycle, while CDK4 and CDK6 are involved in G1 to S progression. CDK6 is essential for cell proliferation within the dentate gyrus of the hippocampus and the cuventricular zone of the lateral ventricles. Mutations in the gene result in microcephaly 12, primary, autosomal recessive (MCPH12).
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-104684_CDK6_Q00534-1_Rabbit.svg, PA5-104684_CDK6_Q00534-1_Rabbit_PDP.jpeg)
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