Thermo Fisher Scientific ATP6V1B1 Monoclonal Antibody (3G11)
ATP6V1B1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(3G11). ELISA에 적합하며 인간 시료에 반응. 친화 크로마토그래피로 정제된 비결합형 액상 항체로, -20°C에서 보관. 세포 내 산성화 연구 및 V-ATPase 관련 연구에 활용 가능.
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Applications
- ELISA (ELISA)
Tested Dilution: 0.3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G11 |
| Immunogen | ATP6V1B1 (NP_001683.2, 1 a.a. ~ 75 a.a) partial recombinant protein with GST tag. MW of GST tag alone: 26 kDa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MAMEIDSRPG GLPGSSCNLG AAREHMQAVT RNYITHPRVT YRTVCSVNGP LVVLDRVKFA QYAEIVHFTL PDGTQ
Target Information
Vacuolar-type H⁺-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process to synthesize ATP.
V-ATPase consists of:
- V1 domain: responsible for ATP hydrolysis (subunits A–H)
- V0 domain: responsible for proton translocation (subunits a, d, c, c′, c″)
The V-ATPase V1 B subunit exists as two isoforms:
- B1 isoform: functions in proton secretion in the inner ear; maintains endolymph pH and auditory function; gene located on chromosome 2cen-q13; mutations cause distal renal tubular acidosis with sensorineural deafness.
- B2 isoform: expressed in kidney and osteoclasts.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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