Thermo Fisher Scientific ATP6V1B1 Monoclonal Antibody (3G11)

Applications

• ELISA (ELISA)
  Tested Dilution: 0.3 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAMEIDSRPG GLPGSSCNLG AAREHMQAVT RNYITHPRVT YRTVCSVNGP LVVLDRVKFA QYAEIVHFTL PDGTQ

Target Information

Vacuolar-type H⁺-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process to synthesize ATP.
V-ATPase consists of:

• V1 domain: responsible for ATP hydrolysis (subunits A–H)
• V0 domain: responsible for proton translocation (subunits a, d, c, c′, c″)

The V-ATPase V1 B subunit exists as two isoforms:

• B1 isoform: functions in proton secretion in the inner ear; maintains endolymph pH and auditory function; gene located on chromosome 2cen-q13; mutations cause distal renal tubular acidosis with sensorineural deafness.
• B2 isoform: expressed in kidney and osteoclasts.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.