Thermo Fisher Scientific ATP6V1A Monoclonal Antibody (4F5)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
TLEVAKLIKD DFLQQNGYTP YDRFCPFYKT VGMLSNMIAF YDMARRAVET TAQSDNKITW SIIREHMGDI LYKLSSMKFK DPLKDGEAKI KSDYAQLLED MQNAFRSLED

Target Information

ATP6V1A encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles.
V-ATPase–dependent organelle acidification is necessary for intracellular processes such as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.

V-ATPase is composed of:

• V1 domain (cytosolic): three A and three B subunits, two G subunits, plus C, D, E, F, and H subunits (contains ATP catalytic site)
• V0 domain (transmembrane): five subunits (a, c, c’, c”, and d)

Additional isoforms of many subunit proteins are encoded by multiple genes or alternatively spliced transcript variants.
This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.