Thermo Fisher Scientific ATP6V1A Monoclonal Antibody (4F5)
ATP6V1A 단백질을 인식하는 Mouse monoclonal antibody (Clone 4F5). WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Human 시료 반응성. Affinity chromatography로 정제된 액상형 항체로, PBS buffer에 보존제 없이 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4F5 |
| Immunogen | ATP6V1A (NP_001681, 508–617 a.a.) 부분 재조합 단백질 (GST tag 포함, GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
TLEVAKLIKD DFLQQNGYTP YDRFCPFYKT VGMLSNMIAF YDMARRAVET TAQSDNKITW SIIREHMGDI LYKLSSMKFK DPLKDGEAKI KSDYAQLLED MQNAFRSLED
Target Information
ATP6V1A encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles.
V-ATPase–dependent organelle acidification is necessary for intracellular processes such as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.
V-ATPase is composed of:
- V1 domain (cytosolic): three A and three B subunits, two G subunits, plus C, D, E, F, and H subunits (contains ATP catalytic site)
- V0 domain (transmembrane): five subunits (a, c, c’, c”, and d)
Additional isoforms of many subunit proteins are encoded by multiple genes or alternatively spliced transcript variants.
This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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