Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI1D6), TrueMAB
HAVCR2(TIM-3) 단백질에 특이적인 Mouse IgG1 단클론 항체로, Western blot 및 유세포분석에 적합. 고순도 친화 크로마토그래피 정제, 동결건조 형태로 제공. 면역관용 및 자가면역 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D6 |
| Immunogen | Full length human recombinant protein of human HAVCR2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It contains an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation, autoimmune disease induction, and immune tolerance regulation. It plays a pathological role in Experimental Autoimmune Encephalomyelitis (EAE), a Th1-dependent autoimmune disease.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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