Thermo Fisher Scientific TRPA1 Polyclonal Antibody, DyLight 550
TRPA1 단백질을 인식하는 DyLight 550 결합 토끼 폴리클로날 항체. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, 4°C 암소 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:250 |
| Immunohistochemistry (Frozen) (IHC (F)) | 0.5–1.0 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-Dependent |
| Flow Cytometry (Flow) | Assay-Dependent |
| ELISA | Assay-Dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Guinea pig, Human, Mouse, Rat, Zebrafish |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 1–100 of human TRPA1 (UniProt ID: O75762-1) |
| Conjugate | DyLight™ 550 |
| Excitation/Emission Max | 556/570 nm |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 50 mM sodium borate |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153529 |
Product Specific Information
- The target sequence has 69% sequence homology with rat.
- Suggested positive control: human brain membrane fraction.
Target Information
TRPA1 is a TRP-related ion channel responsive to cold temperatures and pungent compounds, involved in nociceptor and hair cell transduction. It is associated with transformation in lung epithelial cells and primarily expressed in sensory neurons. Blocking TRPA1 may serve as a therapeutic approach for cold hyperalgesia due to inflammation or nerve injury. TRPA1 is also expressed outside the CNS and is dysregulated during oncogenic transformation. Its structure shares similarity with ankyrin and transmembrane proteins, suggesting roles in signal transduction and growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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