Thermo Fisher Scientific DISC1 Polyclonal Antibody, DyLight 650
DyLight 650으로 표지된 DISC1 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응합니다. 면역조직화학 및 세포면역염색에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 신경세포 DISC1 단백질 연구에 유용합니다.
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Thermo Fisher Scientific DISC1 Polyclonal Antibody, DyLight 650
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5–5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 2.5–5 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to internal region (residues 400–500) of rat DISC1 protein |
| Conjugate | DyLight™ 650 |
| Excitation/Emission Max | 651/673 nm |
| Form | Liquid |
| Concentration | 0.85 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 50 mM sodium borate |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152646 |
Product Specific Information
- Theoretical molecular weight of DISC1: ~90 kDa
- Alternative splicing may yield bands at ~75 and 100 kDa
- Suggested positive control: human brain sections (neurons and glia)
Target Information
DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein interacting with centrosomal and cytoskeletal proteins. It plays a key role in neuronal migration, neurite architecture, and intracellular transport. DISC1 is expressed in several brain regions including hippocampus, cortex, cerebellum, and hypothalamus. Mutations or translocations in the DISC1 gene are associated with schizophrenia. DISC1 interacts with proteins such as MIPT3, MAP1A, NUDEL, α-actinin 2, β4-spectrin, ATF-4, and ATF-5, implicating it in dendritic development and synapse formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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