Thermo Fisher Scientific USP13 Polyclonal Antibody
USP13 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, IP에 사용 가능. 비결합형 액상 형태로 제공되며, 4°C에서 보관. 자가포식 및 단백질 분해 조절 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 175–225 of USP13 (UniProt ID: Q92995-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Bovine.
Target Information
USP13 is a deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2, and USP10, participating in processes including autophagy and endoplasmic reticulum-associated degradation (ERAD).
It is part of a regulatory loop controlling autophagy and p53/TP53 levels by stabilizing key complexes and regulating protein degradation pathways.
USP13 also mediates stabilization of SIAH2 independently of its deubiquitinase activity and preferentially cleaves Lys-63–linked polyubiquitin chains.
It may also cleave ISG15 in vitro, though additional validation is required.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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