Thermo Fisher Scientific USP13 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Product Specifications

Target Information

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2, and USP10, and is involved in processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).
Component of a regulatory loop controlling autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, stabilizing PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability.
Recruited by nuclear UFD1 to mediate deubiquitination of SKP2, regulating ERAD. Also regulates ERAD through deubiquitination of UBL4A, a component of the BAG6/BAT3 complex.
Mediates stabilization of SIAH2 independently of deubiquitinase activity by binding ubiquitinated SIAH2 and impairing its autoubiquitination.
Has weak deubiquitinase activity in vitro and preferentially cleaves Lys-63-linked polyubiquitin chains. Unlike USP5, it cannot mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro, though further validation is needed.
[Source: UniProt]

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

제품 이미지

(이미지 없음)