Thermo Fisher Scientific AUH Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 68-339 of human AUH (NP_001689.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:AUH,uniProtId:Q13825-1,ncbiNodeId:9606,antigenRange:68-339,antigenLength:339,antigenImageFileName:PA5-109434_AUH_Q13825-1_Rabbit.svg,antigenImageFileNamePDP:PA5-109434_AUH_Q13825-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.16 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2854845

Product Specific Information

Immunogen sequence: SSEMKTEDEL RVRHLEEENR GIVVLGINRA YGKNSLSKNL IKMLSKAVDA LKSDKKVRTI IIRSEVPGIF CAGADLKERA KMSSSEVGPF VSKIRAVIND IANLPVPTIA AIDGLALGGG LELALACDIR VAASSAKMGL VETKLAIIPG GGGTQRLPRA IGMSLAKELI FSARVLDGKE AKAVGLISHV LEQNQEGDAA YRKALDLARE FLPQGPVAMR VAKLAINQGM EVDLVTGLAI EEACYAQTIP TKDRLEGLLA FKEKRPPRYK GE

Target Information

The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3` UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40- kDa precursor protein which is subsequently processed to a 32- kDa mature form.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.