Thermo Fisher Scientific Mouse TRANCE (RANKL) Recombinant Protein
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 재고 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
RP8601 | - | Thermo Fisher Scientific RP8601 Mouse TRANCE (RANKL) Recombinant Protein 10 ug pk | 재고문의 | pk | 573,000원 | - | 630,300원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Control (Ctrl)
Assay-dependent
Miscellaneous PubMed (Misc)
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View 1 publication 1 publication
Product Specifications
Species
Mouse
Published species
Not Applicable
Expression System
E. coli
Amino acid sequence
MPAMMEGSWLD VAQRGKPEAQ PFAHLTINAA SIPSGSHKVT LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR HHETSGSVPT DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN WSGNSEFHFY SINVGGFFKL RAGEEISIQV SNPSLLDPDQ DATYFGAFKV QDID
Molecular weight
19.5 kDa
Class
Recombinant
Type
Protein
Purity
≥95%
Endotoxin concentration
≤1 EU/µg
Activity
ED50 ≤ 50 ng/mL; ED50 determined by ability to induce Bioluminescence in engineered RANKL bioassay cells.
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Lyophilized
Concentration
0.1 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.5
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Recombinant mouse RANK Ligand is a non-glycosylated protein containing 175 amino acids.
Reconstitute using sterile water at 0.1 mg/mL and centrifuge prior to opening vial. Gently pipet solution down the sides of the vial. DO NOT VORTEX sample. Store reconstituted material at -20ºC and add 0.1% BSA for additional stability.
Target Information
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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