Thermo Fisher Scientific Human TGF-beta 3 Recombinant Protein
인간 유래 TGF-beta 3 재조합 단백질로 세포 신호전달 및 면역 조절 연구에 적합. E. coli 발현 시스템에서 생산되며 ≥95% 순도와 낮은 엔도톡신 함량(≤0.1 EU/µg)을 가짐. HT-2 세포 증식 억제 활성으로 검증된 고활성 시약. 연구용으로만 사용 가능.
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Applications
- Assay-dependent
Publications
- Miscellaneous PubMed (Misc): None
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Not Applicable |
| Expression System | E. coli |
| Amino Acid Sequence | MALDTNYCFR NLEENCCVRP LYIDFRQDLG WKWVHEPKGY YANFCSGPCP YLRSADTTHS TVLGLYNTLN PEASASPCCV PQDLEPLTIL YYVGRTPKVE QLSNMVVKSC KCS |
| Molecular Weight | 12.9 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥95% |
| Endotoxin Concentration | ≤0.1 EU/µg |
| Activity | ED50 ≤1 ng/mL; determined by the dose-dependent inhibition of HT-2 cell proliferation induced by IL-4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Purified |
| Storage Buffer | 0.01 M acetic acid with 20% ethanol |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
Recombinant human TGF-beta 3 is a non-glycosylated, disulfide-linked homodimer containing two 112 amino acid chains.
Target Information
Transforming growth factor beta 3 (TGF-beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF-beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency-associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer.
As with all members of the family, TGF-beta 3 is highly conserved across species, with mouse and human TGF-beta 3 demonstrating 100% sequence homology and cross-species activity. The members of this family can be expressed by most cell types and exert pleiotropic effects, including:
- Suppression of B- and T-cell effector activity
- Mediation of tissue healing
- Suppression of tumor proliferation
- Promotion of CD4+CD25+ T-cell expansion, indicating a role in protection against autoimmunity
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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