Thermo Fisher Scientific Phospho-WWTR1 (Ser89) Polyclonal Antibody
Phospho-WWTR1 (Ser89) 폴리클로날 항체로, 인산화된 TAZ(Ser89) 특이적 검출에 사용. Western blot에 적합하며 인간, 생쥐, 랫드 시료 반응. PBS 기반 완충액에 50% 글리세롤 포함, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human WWTR1 (Accession Q9GZV5), corresponding to amino acid residues around phosphorylated Ser89. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816539 |
Product Specific Information
This antibody detects endogenous levels of TAZ only when phosphorylated at Ser89.
Target Information
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator acting as a downstream regulatory target in the Hippo signaling pathway, which controls organ size and tumor suppression by restricting proliferation and promoting apoptosis.
The pathway involves a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 with MOB1. MOB1 then phosphorylates and inactivates YAP1 and WWTR1/TAZ.
WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation, regulates nuclear accumulation of SMADS, and couples them to transcriptional machinery such as the mediator complex. It also plays roles in embryonic stem-cell self-renewal, cell proliferation, and epithelial-mesenchymal transition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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