Thermo Fisher Scientific Phospho-WWC1 (Ser947) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human WWC1(Accession Q8IX03), corresponding to amino acid residues around phosphorylated Ser947. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:WWC1,uniProtId:Q8IX03-1,ncbiNodeId:9606,antigenRange:947,antigenLength:1113,antigenImageFileName:PA5-105068_WWC1_Q8IX03-1_Rabbit.svg,antigenImageFileNamePDP:PA5-105068_WWC1_Q8IX03-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2816541

Product Specific Information

Antibody detects endogenous levels of KIBRA only when phosphorylated at Ser947.

Target Information

WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway. This pathway plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2. It acts as a transcriptional coactivator of ESR1 - which plays an essential role in DYNLL1-mediated ESR1 transactivation. WWC1 also functions as a regulatior of collagen-stimulated activation of the ERK/MAPK cascade.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.