Thermo Fisher Scientific KCNMA1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: KCNMA1.

Target Information

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization.
This dual activation is possible because of its structure. The core of the channel, a Maxi K+ alpha homotetramer, contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry, decreasing by 5- to 10-fold the calcium concentration required to keep the pore open.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.