Thermo Fisher Scientific Phospho-TrkA (Tyr496) Polyclonal Antibody
인산화 Tyr496 부위의 TrkA 단백질을 특이적으로 인식하는 rabbit polyclonal antibody. Western blot에 적합하며 인간, 마우스, 랫트 시료에서 반응. 고순도 액상 형태로 제공되며 -20°C에서 보관.
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
Species Reactivity
- Human
- Mouse
- Rat
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NTRK1 (Accession P04629), corresponding to amino acid residues around phosphorylated Tyr496 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816605 |
Product Specific Information
This antibody detects endogenous levels of TrkA only when phosphorylated at Tyr496.
Target Information
NTRK1 (TRKA) belongs to the neurotrophic factor receptor family and plays a key role in the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, undergoes autophosphorylation and activates the MAPK signaling pathway. The presence of TrkA promotes cell differentiation and may influence sensory neuron subtype specification. Mutations in TrkA have been linked to congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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