Thermo Fisher Scientific Phospho-INSR (Tyr1355) Polyclonal Antibody
인간 INSR의 Tyr1355 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot에 적합하며, 인슐린 수용체의 인산화 연구에 활용 가능. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관. 연구용 전용 제품.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human INSR (Accession P06213), corresponding to amino acid residues around phosphorylated Tyr1355 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816608 |
Product Specific Information
Antibody detects endogenous levels of Insulin Receptor only when phosphorylated at Tyr1355.
Target Information
INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine residues in INSR.
In humans, the INSR gene is located on chromosome 19. Defects in INSR are associated with various insulin resistance syndromes, and IGF-1R defects may also lead to certain forms of growth retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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