Thermo Fisher Scientific Phospho-TrkA/TrkB (Tyr785, Tyr816) Polyclonal Antibody
TrkA/TrkB의 Tyr785 및 Tyr816 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot과 Immunocytochemistry에 적합하며, Human, Mouse, Rat에 반응. 1 mg/mL 농도의 액상 형태로 -20°C 보관.
- 카탈로그번호
- PA5105133
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NTRK1 (Accession P04629), corresponding to amino acid residues around phosphorylated Tyr785. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816606 |
Product Specific Information
This antibody detects endogenous levels of TrkA/TrkB only when phosphorylated at Tyr785.
Target Information
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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