Thermo Fisher Scientific Phospho-ATP1A1 (Tyr10) Polyclonal Antibody

Applications and Tested Dilution

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Species Reactivity

Human, Mouse, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ATP1A1 (Accession P05023), corresponding to amino acid residues around phosphorylated Tyr10.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Sequential chromatography

Storage Buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage Conditions

-20°C

Shipping Conditions

Wet ice

RRID

AB_2816607

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Product Specific Information

Antibody detects endogenous levels of ATP1A1 only when phosphorylated at Tyr10.

Target Information

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na⁺/K⁺-ATPases. Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na⁺ and K⁺ ions across the plasma membrane. These gradients are essential for osmoregulation, sodium-coupled transport of various molecules, and electrical excitability of nerve and muscle. The enzyme is composed of two subunits: a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na⁺/K⁺-ATPase is encoded by multiple genes, and this gene encodes the alpha 1 subunit. Multiple transcript variants encoding different isoforms have been identified.

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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.