Thermo Fisher Scientific Phospho-ALK (Tyr1604) Polyclonal Antibody
Phospho-ALK (Tyr1604) 폴리클로날 항체로 인간 ALK 단백질의 인산화 부위를 인식합니다. Western blot, IHC, ICC/IF 등에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 뇌 발달 연구 및 종양 관련 ALK 변이 분석에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (IHC) | - | 2 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 1604 (G-H-Y(p)-E-D) derived from Human ALK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2576543 |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been identified in various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. The most common alteration is chromosomal rearrangement, producing a fusion gene between ALK and the nucleophosmin (NPM) gene. The NPM-ALK fusion gene product is oncogenic. ALK encodes a receptor tyrosine kinase with a transmembrane and extracellular domain, which are absent in the transforming NPM-ALK product. ALK shares high sequence similarity with LTK and plays an important role in neuronal development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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