Thermo Fisher Scientific Phospho-PLK1 (Ser137) Polyclonal Antibody
PLK1 단백질의 Ser137 인산화 부위를 인식하는 Rabbit Polyclonal Antibody입니다. Western blot에 적합하며 Human, Mouse, Rat에 반응합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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- pk
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Thermo Fisher Scientific Phospho-PLK1 (Ser137) Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:3,000
Species Reactivity
- Human
- Mouse
- Rat
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of serine 137 (R-R-S(p)-L-L) derived from Human PLK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608552 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
PLK1 is a serine/threonine kinase involved in cell mitosis and is considered a marker of cell proliferation. It plays a critical role in carcinogenesis. Polo-like kinase proteins bind and phosphorylate proteins that are already phosphorylated on specific motifs recognized by POLO box domains. PLK1 phosphorylates multiple substrates including BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, TP73, TPT1, and WEE1.
PLK1 is essential for centrosome function and bipolar spindle assembly through phosphorylation of KIZ, NEDD1, and NINL.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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