Thermo Fisher Scientific Phospho-CREB (Thr100) Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Phospho-CREB (Thr100) 폴리클로날 항체로 Western blot에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보존. CREB 인산화 연구 및 신호전달 분석에 활용 가능.
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Thermo Fisher Scientific Phospho-CREB (Thr100) Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of threonine 100 (S-G-T(p)-Q-I) derived from Human CREB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609371 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals, including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors.
Activation of CREB depends on phosphorylation of serine 133, mediated by p44/42 MAP kinase, p90RSK, p38 MAP kinase, and MSK1.
Phosphorylated CREB acts as a transcription factor, interacting with CREB binding protein (CBP) at serine 133.
CREB participates in processes such as circadian rhythm synchronization, adipocyte differentiation, and learning and memory.
In humans, the CREB gene is located on chromosome 2q.
Diseases associated with CREB dysfunction include Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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