Thermo Fisher Scientific Phospho-IRAK1 (Thr209) Polyclonal Antibody
Phospho-IRAK1 (Thr209) 폴리클로날 항체로 인간, 마우스, 랫트 반응성. Western blot 및 IHC(P)에서 사용 가능. IRAK1 Thr209 인산화 형태만 검출. 고순도 정제 및 안정적 PBS/glycerol 버퍼 포맷으로 연구용 적합.
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- PA5105183
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IRAK1 (Accession P51617), corresponding to amino acid residues around phosphorylated Thr209 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816656 |
Product Specific Information
- Application note: This antibody has also been used in peptide-ELISA.
- Detects endogenous levels of IRAK1 only when phosphorylated at Thr209.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways.
IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation.
Its association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation.
Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and degradation.
It also phosphorylates interferon regulatory factor 7 (IRF7), inducing activation and nuclear translocation, which triggers transcription of type I IFN genes and antiviral responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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