Thermo Fisher Scientific Phospho-CDK9 (Thr186) Polyclonal Antibody
CDK9 Thr186 인산화 상태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot 및 IHC(P) 검증 완료. 인간, 마우스, 랫트 시료에 반응. 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDK9 (Accession P50750), corresponding to amino acid residues around phosphorylated Thr186. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816654 |
Product Specific Information
Antibody detects endogenous levels of CDK9 only when phosphorylated at Thr186.
Target Information
CDK9 is a serine/threonine kinase which, when complexed with CyclinT1, forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1 and regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors. It promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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