Thermo Fisher Scientific NPR1 Monoclonal Antibody (OTI7H7), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Guanylyl cyclases catalyze the conversion of GTP to cGMP and are classified into soluble and membrane forms.
Membrane guanylyl cyclases (A–F) are cell-surface receptors with:

• Extracellular ligand-binding domain
• Single transmembrane domain
• Intracellular kinase-like and cyclase catalytic domains

GC-A and GC-B act as receptors for natriuretic peptides (atrial and brain types). NPR1 is a membrane-bound guanylate cyclase serving as the receptor for atrial and brain natriuretic peptides (ANP and BNP).
See also NPR3, encoding a related protein with ligand-binding and short cytoplasmic domains.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.