Thermo Fisher Scientific CDKL2 Monoclonal Antibody (OTI5D9), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The activation of signal transduction pathways by growth factors, hormones, and neurotransmitters is mediated by the MAP kinases ERK1 and ERK2. These kinases are regulated by dual phosphorylation at tyrosine and threonine residues within the Thr-Glu-Tyr motif.
The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group and closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain, and lung, and contains the conserved MAP kinase dual phosphorylation motif Thr-Asp-Tyr. It is activated by EGF treatment, but unlike other MAP kinases, this activation does not require phosphorylation at the Thr-Asp-Tyr motif.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.