Thermo Fisher Scientific STAT1 Monoclonal Antibody (OTI13B10), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

STAT1 (Signal Transducer and Activator of Transcription 1) is a member of the STAT family of transcription factors. It is activated by interferons (IFN-α, IFN-β, IFN-γ), EGF, PDGF, and IL-6, and regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism.
STAT1 plays a key role in mediating cell viability in response to various stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2.
Upon activation by JAK kinases, STAT1 translocates to the nucleus to regulate gene transcription. Among the seven STAT proteins, STAT1, STAT3, STAT5a, and STAT5b exhibit broad activation profiles. STAT1 is activated by multiple ligands including IFN family, gp130 family cytokines, and receptor tyrosine kinases.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.