Thermo Fisher Scientific LDHA Monoclonal Antibody (OTI2D11), TrueMAB
LDHA 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot, IHC, IP에 적합. 인간 LDHA 전체 길이 재조합 단백질로 면역화. 동결건조 형태로 제공되며 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific LDHA Monoclonal Antibody (OTI2D11), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunoprecipitation (IP) | 2 µg/500 µL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D11 |
| Immunogen | Full length human recombinant protein of human LDHA produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Lactate dehydrogenase (LDH) is an enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+.
In mammals, LDH is encoded by three genes: LDHA (muscle form), LDHB (heart form), and LDHC (testis form).
The three human LDHs share 84–89% sequence similarity and 69–75% amino acid identity.
There are five isoenzymes based on the proportion of M and H chains in the tetrameric structure.
LDHA expression is hypoxia-inducible and regulated by HIF1a transcriptional activity.
LDHB is upregulated in many cancers.
Mutations in LDHA can cause Glycogen Storage Disease 11 (GSD11).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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