Thermo Fisher Scientific LDHA Monoclonal Antibody (OTI2D11), TrueMAB

Thermo Fisher Scientific LDHA Monoclonal Antibody (OTI2D11), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Lactate dehydrogenase (LDH) is an enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+.
In mammals, LDH is encoded by three genes: LDHA (muscle form), LDHB (heart form), and LDHC (testis form).
The three human LDHs share 84–89% sequence similarity and 69–75% amino acid identity.
There are five isoenzymes based on the proportion of M and H chains in the tetrameric structure.
LDHA expression is hypoxia-inducible and regulated by HIF1a transcriptional activity.
LDHB is upregulated in many cancers.
Mutations in LDHA can cause Glycogen Storage Disease 11 (GSD11).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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