Thermo Fisher Scientific MAP1 Polyclonal Antibody
MAP1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 사멸 연구 및 Bcl-2 패밀리 단백질 분석에 활용됩니다.
- 카탈로그번호
- PA519995
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific MAP1 Polyclonal Antibody
Applications
- Western Blot (WB): 1–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the center of human MAP-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months; for long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152924 |
Product Specific Information
- Suggested positive control: EL4 cell lysate
- PA5-19995 can be used with blocking peptide PEP-0117
Target Information
Apoptosis plays a major role in organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process is implicated in diseases such as cancer. Members of the Bcl-2 family regulate apoptosis through conserved Bcl-2 homology (BH) domains. MAP-1, a related protein containing a BH3-like domain, induces caspase-dependent apoptosis when overexpressed. It forms homodimers and interacts with Bcl-2 family members (Bax, Bcl-2, Bcl-XL) both in vitro and in vivo. MAP-1 also associates with tumor suppressor RASSF1A following death receptor activation, leading to Bax conformational change and cellular apoptosis.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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