Thermo Fisher Scientific Livin Polyclonal Antibody
Livin 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 인간 Livin 단백질에 반응. 냉장 및 장기 보관 시 안정적.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 264–280 of the short form and 281–298 of the long form of human Livin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156011 |
Product Specific Information
- In Western blot applications, this antibody detects a band at approximately 33 kDa.
- Suggested positive control: Raji cell lysate.
- PA5-19990 can be used with blocking peptide PEP-0114.
Target Information
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif essential for anti-apoptotic activity.
Livin (also known as ML-IAP) is a human IAP family member containing a single BIR domain and a C-terminal RING finger domain.
Livin gene has two splice variants (298 and 280 amino acids), both containing BIR and RING domains. Both isoforms inhibit TNFα-induced apoptosis in Jurkat cells.
Livin expression is low in adult tissues but higher in developmental tissues and many cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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