Thermo Fisher Scientific CD93 (AA4.1) Monoclonal Antibody (AA4.1), FITC, eBioscience

Applications

• Flow Cytometry (Flow): Tested at ≤ 1 µg/test
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Product Specifications

Available Formats

• APC (Cat. 17-5892-82)
• Biotin (Cat. 13-5892-82)
• eFluor 450 (Cat. 48-5892-80)
• PE (Cat. 12-5892-82)
• PE-Cyanine7 (Cat. 25-5892-82)
• PerCP-Cyanine5.5 (Cat. 45-5892-82)
• Super Bright 436 (Cat. 62-5892-82)
• Super Bright 600 (Cat. 63-5892-82)
• Super Bright 702 (Cat. 67-5892-82)
• Request custom conjugation

Product Specific Information

The AA4.1 monoclonal antibody recognizes mouse C1qRp, a 130–140 kDa C-type lectin-like type I transmembrane protein. The AA4.1 antigen is expressed on early B cell developmental stages in bone marrow, as well as in adult spleen and fetal liver.
When combined with markers such as Thy-1, Sca-1, c-Kit, CD43, and CD24, the AA4.1 antigen helps distinguish primitive and differentiated lymphoid progenitor subsets.
Expression of surface IgM, CD23, and AA4.1 defines three immature B cell subsets:

• T1: AA4.1⁺ / CD23⁻ / sIgM^hi
• T2: AA4.1⁺ / CD23⁺ / sIgM^hi
• T3: AA4.1⁺ / CD23⁺ / sIgM^lo

AA4.1 is also detected in endothelial cells, megakaryoblasts, and platelets. The AA4.1 and 493 antibodies recognize different epitopes of the same molecule.

Applications Reported: Flow cytometric analysis
Applications Tested: Tested on mouse bone marrow and splenocytes at ≤ 1 µg/test
Recommended Use: Optimize antibody titration for best performance
Excitation: 488 nm
Emission: 520 nm
Laser: Blue
Filtration: 0.2 µm post-manufacturing filtered

Target Information

The encoded protein is a type I membrane glycoprotein originally identified as a myeloid cell marker. It is implicated in intercellular adhesion and apoptotic cell clearance. The cytoplasmic tail interacts with moesin, linking it to cytoskeletal remodeling processes.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.

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