Thermo Fisher Scientific Phospho-EGFR (Ser967) Polyclonal Antibody
EGFR 단백질의 Ser967 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 면역세포염색에 적합. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제, 고순도 액상 형태.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-EGFR (Ser-967) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding serine 967 of human EGFR (ErbB-1). This human EGFR sequence has high homology to rat and mouse EGFR, and low homology to other ErbB family members. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942921 |
Product Specific Information
This antibody was cross-adsorbed to unphosphorylated EGFR (Ser-967) coupled to agarose, then affinity purified using phospho-EGFR (Ser-967) peptide (without carrier).
It detects a 180 kDa* protein on SDS-PAGE immunoblots of human A431 cells treated with Calyculin A, and does not detect this band after lambda phosphatase treatment.
Target Information
EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that signals in response to various growth factors.
Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics.
EGFR is encoded by the EGFR gene located on chromosome 7 in humans and belongs to the HER/ERbB family of proteins (ERbB2, ERbB3, ERbB4).
Binding of ligands such as EGF and TGF-alpha to the extracellular domain leads to EGFR dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain.
Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and in squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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