Thermo Fisher Scientific SHANK1 Monoclonal Antibody (N22/21), APC
SHANK1 단백질을 인식하는 Thermo Fisher Scientific의 APC 형광 표지 단일클론 항체입니다. Western blot, IHC, ICC/IF 등 다양한 분석에 사용 가능하며, 인간, 마우스, 랫트 반응성을 가집니다. 단백질 G 정제, 4°C 보관, 연구용 전용 제품입니다.
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Thermo Fisher Scientific SHANK1 Monoclonal Antibody (N22/21), APC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N22/21 |
| Immunogen | Fusion protein amino acids 469–691 (SH3/PDZ domains) of rat Shank1 |
| Conjugate | APC |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931900 |
Additional Formats
- Unconjugated (MA5-27626)
- FITC (MA5-45447)
- PE (MA5-45449)
- PerCP (MA5-45448)
- Request custom conjugation
Product Specific Information
1 µg/mL of MA5-45446 was sufficient for detection of Shank1 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 190–220 kDa (alternative splice variants).
No cross-reactivity against Shank2 or Shank3.
Target Information
SHANK1 is an adapter protein located in the postsynaptic density (PSD) of excitatory synapses. It interconnects receptors of the postsynaptic membrane, including NMDA-type and metabotropic glutamate receptors, via complexes with GKAP/PSD-95 and Homer, and links to the actin-based cytoskeleton.
It plays a key role in the structural and functional organization of dendritic spines and synaptic junctions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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