Thermo Fisher Scientific SHANK2 Monoclonal Antibody (N23b/6), FITC
SHANK2 단백질을 인식하는 FITC 결합 단클론 항체로, 신경 시냅스 단백질 연구에 적합합니다. Western blot, IHC, ICC/IF, IP, AM 등 다양한 응용에 사용 가능하며, 498/517 nm 형광 특성을 가집니다. 4°C 암소 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:1,000 | |
| Immunohistochemistry (IHC) | 1:1,000 | |
| Immunocytochemistry (ICC/IF) | 1:100 | |
| Immunoprecipitation (IP) | Assay-dependent | |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N23b/6 |
| Immunogen | Fusion protein amino acids 84–309 (SH3/PDZ domains) of rat Shank2 (SH3 and multiple ankyrin repeat domains protein 2) |
| Conjugate | FITC (Fluorescein) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- 1 µg/mL of MA5-45443 was sufficient for detection of Shank2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Detects approximately 160 kDa.
- No cross-reactivity against Shank1 or Shank3.
- Weak mouse detection.
Target Information
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses.
Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats and an SH3 domain.
This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides, and a sterile alpha motif.
Alternative splicing demonstrated in Shank genes may regulate the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain.
Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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